Perricone MD Review

About Perricone MD

Perricone MD Review

Perricone MD is a New York Times-featured luxury healthcare brand, focusing on providing science-backed skincare products. They won a 2020 Harper’s Bazaar award for their Vitamin C Ester Brightening Serum.

As life expectancy grows, people are more concerned about their appearance. According to Justine Coupland[1], the face is the most exposed part of the body and has a symbolic significance. Taking care of our skin and preventing photodamage are measures that play an essential role in our self-esteem and overall confidence.

In this Perricone MD review, we’ll dive into the purpose of their products, how to use them, shipping and return policies, and more. We’ll answer a range of questions you probably never thought of—all so you can make informed and appropriate purchasing decisions.

Why You Should Trust Us

Our mission is to help you make better, more informed purchase decisions. 

Our team spends hours researching, consulting with medical experts, gathering insight from expert professionals, reviewing customer feedback, and analyzing products to provide you with the information you need.

Overview Of Perricone MD

Perricone MD Review

Dr. Perricone created Perricone MD in 1997 under the name Clinical Creations.

Along the way, the company was the first doctor-led brand to launch at Sephora. It established itself as a thriving e-commerce skincare store in 2001 and even published a #1 New York Times best-selling book called The Wrinkle Cure.

Dr. Perricone went on to write a second volume but also decided to focus on breakthrough beauty treatments, including Cold Plasma products and The No Makeup Collection (cosmetics infused with skincare properties).

Today, Perricone MD believes in treating yourself from the inside out and the outside in. A healthy diet, nutritional supplements, and potent topical skincare create its three-tier philosophy of success. 

Pros & Cons

Perricone MD’s goal is to promote healthy skin through clinical and holistic approaches. Before we get into how the brand delivers on them, let’s take a look at some of their pros and cons:


  • Scientifically-backed ingredients: Perricone MD products are formulated with scientifically-backed ingredients such as alpha-lipoic acid, DMAE, and retinol. These ingredients are known to improve skin texture, reduce fine lines and wrinkles, and promote skin elasticity.
  • Wide range of products: Perricone MD offers a wide range of products, including cleansers, moisturizers, serums, and treatments. This allows customers to create a personalized skincare routine based on their specific needs.
  • Cruelty-free and vegan options: Perricone MD offers cruelty-free and vegan options for customers who prefer products that are not tested on animals and do not contain animal-derived ingredients.
  • Positive customer reviews: Many customers have reported positive results after using Perricone MD products, including improved skin texture and reduced fine lines and wrinkles.


  • High price point: Perricone MD products are generally more expensive than other skincare brands. This can be a barrier for some customers who are on a budget.
  • Potentially irritating ingredients: Some customers have reported skin irritation after using products that contain alpha-lipoic acid or retinol. These ingredients can be harsh on sensitive skin, so it’s important to do a patch test before using a new product.


Here are some features of Perricone MD skincare products:

  1. Science-based formulations: Perricone MD skincare products are formulated based on Dr. Perricone’s research in the field of dermatology and anti-aging. The brand uses advanced technologies and ingredients to create skincare products that target specific skin concerns.
  2. Anti-aging properties: Many of the brand’s products are designed to reduce the appearance of fine lines, wrinkles, and other signs of aging. The ingredients used in these products are chosen for their ability to improve skin elasticity, firmness, and texture.
  3. Nutrient-rich ingredients: Perricone MD skincare products are formulated with ingredients that are rich in nutrients, such as antioxidants, vitamins, and minerals. These ingredients help to nourish and protect the skin from environmental stressors that can cause damage.
  4. Multiple product lines: Perricone MD offers a range of product lines that cater to different skin concerns, such as acne-prone skin, dry skin, and sensitive skin. Each product line is formulated with ingredients that address specific concerns and needs.
  5. Cruelty-free and vegan options: Perricone MD is committed to using cruelty-free and vegan ingredients in its products. The brand does not test on animals and many of its products are certified vegan by PETA.


Perricone MD products contain a variety of ingredients that are intended to address different skin concerns. Here are some of the ingredients commonly used by Perricone MD and the scientific evidence behind their inclusion:

  1. Alpha Lipoic Acid: Alpha Lipoic Acid (ALA) is an antioxidant that has been shown to protect skin from damage caused by free radicals. It has also been found to improve skin texture, reduce fine lines, and increase skin firmness.
  2. Vitamin C: Vitamin C is a potent antioxidant that can help protect the skin from oxidative stress and sun damage. It has also been shown to reduce hyperpigmentation and improve skin tone.
  3. Retinol: Retinol is a form of vitamin A that has been shown to improve skin texture and reduce the appearance of fine lines and wrinkles. It works by increasing cell turnover and stimulating collagen production.
  4. DMAE: DMAE (Dimethylaminoethanol) is a compound that has been found to improve skin firmness and reduce the appearance of fine lines and wrinkles. It works by increasing the production of acetylcholine, a neurotransmitter that helps to firm and tighten the skin.
  5. Phosphatidylcholine: Phosphatidylcholine is a type of lipid that is found naturally in cell membranes. It has been shown to help repair and strengthen the skin barrier, which can improve skin hydration and reduce the appearance of fine lines and wrinkles.

Health Benefits

Perricone MD claims that their products offer various benefits for the skin, such as reducing the appearance of fine lines and wrinkles, improving skin texture and tone, and promoting a more youthful, radiant complexion.

Improve the appearance of fine lines and wrinkles

Ingredients such as Alpha Lipoic Acid (ALA) have been shown to improve the appearance of fine lines and wrinkles, as well as skin texture and tone.

Improve skin texture and tone

The inclusion of DMAE and retinol help with their anti-aging properties to reduce the appearance of fine lines and wrinkles.

Promote a more youthful, radiant complexion

The powerhouse that is Vitamin C can help protect from sun damage and imbue a healthy glow by improving skin tone.

10 Best-Selling Perricone MD Skincare Products

Perricone MD products are split into Skincare, Supplements, No Makeup, Acne Relief, and Regimens categories.

This review’s primary focus is the best-selling Skincare, No Makeup, and Acne Relief products. We will examine ingredients, usage instructions, pricing, and more.

Perricone MD No Makeup Foundation Review

The No Makeup Foundation gives you a sheer, luminous base. It sets the stage for a more uniform complexion. It evens out your skin tone by visibly concealing discoloration and providing moisture. 

Expect a dewy finish, with added broad spectrum SPF 20 for sun protection. Some customers love No Makeup Foundation while others complain about the new formula. But, overall, reviews are happy about the glowing skin it produces. You can purchase it for $60.

Perricone MD No Makeup Lipstick Review

Lip aging involves loss of volume, dehydration, and wrinkles. In a clinical study[2] conducted in the US, 36 women with lip dryness applied hyaluronic acid lipstick three times a day for a month.

Results showed instant and long-term effects improving texture, definition, scaling, cupping, wrinkles, plumpness, and overall lip condition.

Cushiony and skincare-infused, the No Makeup Lipstick promises to give you the same results. It moisturizes, protects, and gives your lips a pop of color. Plus, it visibly improves lip firmness, smoothness, and definition.

In this formula, neuropeptides fight off sagging, while hyaluronic acid is the agent behind lasting hydration. Although it may be gentle enough on your skin, it contains advanced SPF Protection to shield you from sun damage.

Overall, the No Makeup Lipstick is a great option for anyone serious about their lips. It is available for $30.

Perricone MD No Makeup Blush Review

No Makeup Blush gives your cheeks a natural flush. If your skin is looking a little sullen or pale in the winter months, apply some of this to look alive again. The buildable coverage gives you the freedom to create a glow as subtle or prominent as you wish. 

This gel cream blends easily and stays on all day, more forgiving on wrinkles than powder blush. Vitamin C ester and Chinese ginger plant extract work together and form a smooth antioxidant experience for your skin.

Although evidence is still limited, a literature review[3] describes that topical application of Vitamin C has anti-aging, anti-pigmentary, and photoprotective effects.

Perricone MD Vitamin C Ester Brightening Serum Review

Some skincare products promise a never-ending list of amazing benefits at the price of terribly pungent formulas. We pinch our noses when applying these potions, making the sacrifice. Thankfully, the Vitamin C Ester Brightening Serum is neutral—some users even love the scent!

Plus, it stands up to its tall claims of enhancing natural radiance and smoothing out texture. The potent Vitamin C serum is mixed with squalene and rosemary leaf extracts to shrink your pores and wake up your skin.

It’s widely known that vitamin c stimulates the synthesis of collagen. However, when applied topically, it cannot penetrate the epidermal barrier.

A recently published study[4] combined vitamin C with squalane (a skin lipid). Compared to other vitamin C formulas, their preparation achieved way better skin penetration and significantly increased collagen production.

The brand recommends applying a hyaluronic acid-packed lotion after using the serum.

You can purchase the Vitamin C Ester Brightening Serum on the Perricone MD website for $69.

Perricone MD High Potency Classics Firming Eye Lift Review

The High Potency Classics Firming Eye Lift is driven to improve one thing…You probably guessed it: lifting and firming the delicate skin around your eyes.

It won’t produce dramatic results right away; eye creams are more effective when incorporated into your nighttime routine and used diligently. 

You’ll observe shrinking crow’s feet and decreased puffiness in a day or two. Dark circles take a little more time to dissipate.

Through a formula reliant on hyaluronic acid, DMAE, and squalane, the High Potency Classics Firming Eye Lift goes on smoothly and absorbs quickly into the skin

Hyaluronic acid is a component of the extracellular matrix with water retention capacity. As described in a review article[5], hyaluronic acid dramatically decreases in aged skin resulting in loss of skin moisture. DMAE is a precursor of the neurotransmitter acetylcholine.

In a literature review[6] about the skin reparative properties of DMAE, the authors concluded that it increases skin firmness and may have anti-inflammatory activity.

You can buy the High Potency Classics Firming Eye Lift now for $72.

Perricone MD High Potency Growth Factor Firming & Lifting Serum Review

The High Potency Growth Factor Firming & Lifting Serum is a powerful way to give skin that coveted plump, bouncy look, but also develop its resilience against the effects of aging.

The special Encapsulated Retinol technology means it may feel gritty at first, but don’t be alarmed. This is intended so that the retinol can be soaked into your skin more easily and support its moisture barrier.

The anti-aging efficacy of retinol has been demonstrated in several studies. A review[7] published in the American Journal of Clinical Dermatology found substantial evidence regarding topical retinoids in the treatment of photoaged skin.

Retinol improves the overall appearance of aged skin by reducing wrinkles, inelasticity, pigmentation, and roughness. Common side effects[8] include skin irritation, redness, and skin desquamation (peeling). It is not recommended to use retinoids during pregnancy.

When it comes back in stock, High Potency Growth Factor Firming & Lifting Serum will be available for $129. This is the perfect time to sign up for Perricone MD’s newsletter, so you’ll be the first to grab this in-demand serum when it’s back. 

Perricone MD Neuropeptide Firming Moisturizer Review

This Perricone MD moisturizer is the real deal. It effectively helps restore the elasticity of thin, frail skin through deep hydration.

Ultra-powerful and creamy, the Neuropeptide Firming Moisturizer provides all-day softness. The formula contains phosphatidylcholine, which is a major component in human skin cells.

When applied topically, it increases skin hydration[9].  Apply a small amount under makeup or after using Perricone MD’s Vitamin C Ester Brightening serum.

Its promise is a younger-looking complexion and intensive firming. Neuropeptide Firming Moisturizer is the culmination of twenty years of research and the most advanced firming moisturizer that Perricone MD has to offer—which is why it costs an eye-popping $290.

Perricone MD Cold Plasma Review

Based on Vitamin C Ester, Omegas 3, 6 & 9, and Copper Tripeptide, the Cold Plasma+ Advanced Serum Concentrate is an advanced remedy that promotes supple skin. All at once, it heals dullness, redness, large pores, deep creases, and more. 

Although there is little evidence, a nutraceuticals review[10] published in Dermatology and Therapy highlights that omega fatty acids have anti-inflammatory properties in the skin. At the same time, copper induces collagen synthesis and may have skin anti-aging, anti-inflammatory, antibacterial, and wound-healing effects.

Coming in at a one-time purchase of $149 the Cold Plasma+ Advanced Serum is a multi-tasking product that doesn’t skimp on any of the benefits.

For results that will win compliments at the next social gathering, combine this serum with Perricone MD’s Cold Plasma Plus+Sub-D/Neck, which we’ll get into next. 

Perricone MD Cold Plasma Plus+ Sub-D/Neck Review

The Cold Plasma Plus+ Sub-D/Neck is one of Perricone’s most established neck treatments.

It is designed to slow the signs of aging and give a sculpted jawline, keeping everything taut and graceful. In an 8-week clinical study, 85% of people had improved skin elasticity, while 76% noticed redness disappearing.

The Cold Plasma Plus+ Sub-D/Neck has a formula packed with DMAE for firming, peptides for fortifying against damage, and an all-natural skin-tightening stimulant. You can pick this product up for $135

Perricone MD Cold Plasma Plus Duo Review

Makeup can temporarily veil blemishes and sallow complexions. Eventually, long-term neglect will start to shine through, always holding you back. To combat recurring skin problems at a more foundational level, bring Cold Plasma Plus+ Duo into your skincare regime.

The Cold Plasma Plus+ Duo penetrates deep to correct damage and discoloration for a more polished look. After achieving velvet-smooth skin, you might even be compelled to toss out those full-coverage concealers. 

This fragrance-free product is also marked down to $199 from $259.

Who Is Perricone MD For?

Perricone MD offers a range of skincare products that target various skin concerns and types. According to the brand’s website, the products are suitable for all skin types, including sensitive skin.

Perricone MD is marketed towards individuals who are looking to improve the appearance and health of their skin. The brand also targets those who are concerned about signs of aging, such as fine lines and wrinkles, and those who want to maintain a youthful-looking complexion.

Overall, Perricone MD caters to individuals who are interested in premium skincare products and are willing to invest in their skincare routine.

Perricone MD Reviews: What Do Customers Think?

Perricone MD Review

Is Perricone a good product?  The brand received an average of 4/5 stars on their website, with very few outliers as of May 2023. That’s a heck of a great start to this section.

One 5-star review for the Cold Plasma Plus Duo+ shared that it was compatible with mature, sensitive skin. She echoed the sentiments of many, in saying that Perricone MD’s moisturizers are best paired with some of their more drying serums. Her testimonial reads: 

“I have fair, sensitive and aging skin and harsh chemicals send me to the emergency room.  That is why Perricone MD’s Cold Plasma products are right for me.  I use them twice a day on my face and eyes after serum or toner for good, thorough coverage to lock in moisture.  A finishing cream with sun protection or a moisturizing cream is the final step.”

On Sephora, Perricone customers are in love and gave the brand a 4/5 star average based on thousands of reviews.

A buyer left this Perricone MD Face Finishing Moisturizer review: “This cream is SO good and left my skin looking younger and healthier almost instantly!! but I had to give it four stars because it made me break out SO much.”

On Trustpilot, Perricone MD received 4.6/5 stars. And while all the positive feedback from customers is reassuring, there were some common gripes amongst shoppers. For the most part, reviewers claimed that products were too expensive to repurchase, but most agreed that they saw satisfying results.

Is Perricone MD Worth It?

Perricone MD Review

The verdict of this Perricone MD review is that the brand is worth it. They have great customer reviews overall, a huge selection of products that treat multiple skin issues, and they use clinically-proven ingredients to promote healthier-looking skin.

That said, Perricone’s recent acquisition by The Hut Group has left many customers disappointed in the recent changes to their favorite formulas. To be sure, customers still regularly leave 5-star reviews, but some of their fanbase has started to drift away.

As a result, we recommend keeping up with news of the brand before you decide to make a purchase. Take a look at your favorite formulas as well to observe any changes before pressing “add to cart”!

Perricone MD Promotions & Discounts

Perricone MD Review

For this Perricone MD review, we sleuthed out many discounts for our readers. For starters, customers can always take advantage of the Auto Replenishment subscription to save a few more dollars. The program is risk-free; you can cancel at any time. 

Additionally, the brand is offering a free full-size Cold Plasma Plus+ gift with the purchase of The Intensive Hydrating Complex.  We also found more standard discounts:

  • 15% off initial orders
  • 30% off recurring orders of No Makeup products under their skincare line 
  • 40% off recurring orders of Supplements and Acne Relief

In terms of promotion codes, these are time-sensitive ones currently advertised on their website: 

  • With the code NMSEVENTNMSEVENT, you’ll save 40–50% on their No Makeup Skincare Event
  • Celebrate Mom sale for 25% off gift sets. Use the code FORMOM to activate your savings.

There’s more—this Perricone MD review isn’t done listing the discounts yet! Anyone who spends $125+ at checkout can select their own gift

While we’re not entirely sure what the gift exactly entails, it’s clear that students (who verify their status and register) get a special 50% discount through Perricone MD’s program, “Student Beans”.

Perricone MD warehouse sales may also be available from time to time, so sign up as a member and keep an eye on your email inbox.

Where To Buy Perricone MD

Perricone MD Review

Perricone MD is available to buy on their website: Their products are also available at a number of retailers such as: 

  • Amazon
  • Walmart
  • Sephora
  • Look Fantastic
  • Skinstore
  • Ulta Beauty
  • Nordstrom


To help you out on the search for the perfect skincare products, here are a few more options to consider:

  1. Sunday Riley – Sunday Riley is a skincare brand that offers high-performance formulas with clean and botanical-based ingredients. The brand focuses on natural ingredients and cutting-edge technology to deliver effective results.
  2. Drunk Elephant – Drunk Elephant is a clean beauty brand that offers skincare products with a focus on natural and non-toxic ingredients. The brand’s philosophy is to use only ingredients that directly benefit the skin, without any “fillers” or unnecessary additives.
  3. Osea – Osea is a natural and vegan skincare brand that offers products made with sustainably sourced, organic ingredients. The brand’s formulations are designed to nourish and protect the skin without any harsh chemicals or synthetic fragrances.
  4. Tata Harper – Tata Harper is a luxury skincare brand that offers products made with natural and organic ingredients. The brand’s formulations are free from synthetic chemicals and are designed to be gentle and effective on all skin types.


Perricone MD Review

Who owns Perricone skincare?

Perricone skincare is owned by The Hut Group, which acquired it for $60 million in 2020. The Hut Group was founded by British businessman Matthew Moulding and owns many cosmetics and personal care brands.

Is Perricone MD a clean brand?

Based on all the research for this Perricone MD review, we can confidently report that it is a clean brand. Their products are safe, award-winning, and effective for treating a wide assortment of dermal complications. The Perricone diet and their supplements are additional ways for customers to strengthen their skin and body.

Does Perricone MD have retinol?

Some Perricone MD serums have retinol. It is a critical and highly recommended ingredient for promoting collagen development, decreasing acne and hyperpigmentation.

Is Perricone MD all-natural?

No, Perricone MD is not all-natural. While their products do contain many natural ingredients, some also include clinical-level acids and formulas to address long-standing skin issues.

Is Perricone MD good for acne?

Perricone MD has a whole category of products dedicated to getting rid of acne. Their simple two-step skincare system works with your skin to improve acne issues.

Is Perricone MD good for sensitive skin?

It absolutely is. As far as Perricone MD reviews go, customers reported great effects on sensitive and mature skin, and some items in their wide range of products were specifically designed for this issue.

How do I know when my Perricone MD expires?

Most Perricone MD products, like Perricone MD Blue Plasma, come with an expiration date. Be sure to carefully check your packaging and the bottle itself to find how long it will be effective.

What is Perricone MD’s Shipping Policy?

Perricone MD offers free standard shipping on orders of $75 or over. Read the short guide below for more details on Perricone MD‘s shipping policy.

US Standard Shipping

  • Arrives within 7–9 business days
  • Costs $6 for orders under $75
  • Orders over $75 are free

US Express Shipping

  • Arrives within 2–3 business days
  • Charges $10 for orders of any amount
  • Order before 4 PM CST

US Premium Shipping

  • Arrives within 1–2 business days
  • Costs $20 for orders of any amount
  • Order before 4 PM CST

International Delivery

  • Delivery expected within 10–14 business days
  • Orders must be 4.4lbs or under
  • Shipping costs $15 for orders of any amount
  • Deliveries outside the US could result in import duties and taxes (including VAT)

What is the Perricone MD Returns Policy?

This Perricone MD review has a simple guide to making a return. Note, only damaged, faulty, or unopened items can be returned for a refund. 

Follow the steps provided below for a successful return:

1. Prepare your order number, which can be found in your order confirmation email

2. Prepare photographic evidence of damaged or faulty items, if applicable

3. Log in to your Perricone MD account and message customer support by email or live chat

4. Talk to one of Perricone MD’s advisors

5. Receive a Returns Authorization Number

6. If the return request is accepted for a damaged or faulty item, a pre-paid returns label will be sent to your email address

7. Print the pre-paid returns label and attach it to your package

8. Mail your items back to Perricone MD

9. Receive your refund within 14 days of the return package being received

How to contact Perricone MD

Perricone MD’s Live Chat support function is currently not working, so customers have three options: 

  • Call customer service: 888-823-7837 (Monday–Friday, between 9AM and 6PM ET) 
  • Sign in to your Perricone MD account and send a message
  • Send them a direct message on Facebook, Twitter, or Instagram

We know how important skincare is! Check out our reviews for other top skincare brands:

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True Botanicals

Tiege Hanley

Article Sources

[1] Coupland, J. Ageist Ideology and Discourses of Control in Skincare Product Marketing Springer Link In Discourse, the body, and identity (pp. 127-150). Palgrave Macmillan, London
[2] Makino, E. T., Tan, P., Qian, K., Babcock, M., & Mehta, R. C. Clinical Assessment of Immediate and Long-Term Effects of a Two-Step Topical Hyaluronic Acid Lip Treatment Journal of drugs in dermatology : JDD, 16(4), 366–371
[3] Al-Niaimi, F., & Chiang, N. Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications The Journal of clinical and aesthetic dermatology, 10(7), 14–17
[4] Gref, R., Deloménie, C., Maksimenko, A., Gouadon, E., Percoco, G., Lati, E., ... & Couvreur, P. Vitamin C–squalene bioconjugate promotes epidermal thickening and collagen production in human skin Scientific reports, 10(1), 1-12
[5] Papakonstantinou, E., Roth, M., & Karakiulakis, G. Hyaluronic acid: A key molecule in skin aging Dermato-endocrinology, 4(3), 253-258
[6] Grossman, R. The Role of Dimethylaminoethanol in Cosmetic Dermatology American journal of clinical dermatology, 6(1), 39-47
[7] Riahi, R. R., Bush, A. E., & Cohen, P. R. Topical Retinoids: Therapeutic Mechanisms in the Treatment of Photodamaged Skin Springer Link American journal of clinical dermatology, 17(3), 265-276
[8] Kang, H. Y., Valerio, L., Bahadoran, P., & Ortonne, J. P. The Role of Topical Retinoids in the Treatment of Pigmentary Disorders Springer Link American journal of clinical dermatology, 10(4), 251-260
[9] Ghyczy, M., & Vacata, V. Phosphatidylcholine and Skin Hydration In Skin moisturization (pp. 327-346). CRC Press
[10] Souyoul, S. A., Saussy, K. P., & Lupo, M. P. Nutraceuticals: A Review Springer Link Dermatology and Therapy, 8(1), 5-16

Ask the community or leave a comment

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About my account
Asked by Carime Quezada (3 years ago) Reply

They overcharged me

Answered by Carime Quezada (3 years ago) Reply

I was overcharged

Extremely Dissatisfied
Asked by Elizabeth Melanz (2 years ago) Reply

I used the Growth Factor Firming and Liftimg Serum and Brightening Serum for approximately six months. During that time I saw no visible results, therefore I let it go. I tried other products from The Ordinary and some results within two weeks. Decreased dark spots, brighter and firmer feeling. And at major fraction of the cost. Major lesson learned, brand name and price does not equal results. What was promoted/promised from this high end brand definitely did not deliver!

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