Perricone MD Review

About Perricone MD

Perricone MD Review

Perricone MD is a New York Times featured luxury healthcare brand, focusing on providing science-backed skincare products. They won a 2020 Harper’s Bazaar award for their Vitamin C Ester Brightening Serum.

As life expectancy grows, people are more concerned about their appearance. According to Justine Coupland[1], the face is the most exposed part of the body and has a symbolic significance. Taking care of our skin and preventing photodamage are measures that play an essential role in our self-esteem and overall confidence.

This Perricone MD review dives into the purpose of their products, how to use them, shipping and return policies, and more. We answer a range of questions you probably never thought of—all so you can make informed and appropriate purchasing decisions.

Overview of Perricone MD

Perricone MD Review

Dr. Perricone created Perricone MD in 1997 under the name Clinical Creations. Along the way, the company was the first doctor-led brand to launch at Sephora. It established itself as a thriving e-commerce skincare store in 2001 and even published a #1 New York Times best-selling book called The Wrinkle Cure.

Dr Perricone went on to write a second volume, but also decided to focus on breakthrough beauty treatments, including Cold Plasma products and the No Makeup collection (cosmetics infused with skincare properties).

Today, Perricone MD believes in treating yourself from the inside-out and the outside-in. A healthy diet, nutritional supplements, and potent topical skincare create its three-tier philosophy of success. 

Their goal is to promote healthy skin through clinical and holistic approaches. Before we get into how the brand delivers on them, let’s take a look at some of its highlights:


  • Many categories of personal care products offered  Skincare items are compatible with mature, sensitive skin and formulated with high-quality ingredients. 
  • Auto-replenishment subscription available
  • High customer approval rating
  • Savings and discounts for Perricone MD members up to 30%
  • Membership can be canceled at any time
  • Many options for delivery frequency
  • Fast shipping
  • Uses Afterpay for payment installments

Perricone MD Skincare Review

Perricone MD products are split into Skincare, Supplements, No Makeup, Acne Relief, and Regimens categories. This review’s primary focus is the best-selling Skincare, No Makeup, and Acne Relief products. We will examine ingredients, usage instructions, pricing, and more.

Perricone MD No Makeup Foundation Review

No Makeup Foundation gives you a sheer, luminous base. It sets the stage for a more uniform complexion. It evens out your skin tone by visibly concealing discoloration and providing moisture. 

Expect a dewy finish, with added broad spectrum SPF 20 for sun protection. Some customers love No Makeup Foundation while others complain about the new formula. But, overall, reviews are happy about the glowing skin it produces. You can purchase it for $60.

Perricone MD No Makeup Lipstick Review

Lip aging involves loss of volume, dehydration, and wrinkles. In a clinical study[2] conducted in the US, 36 women with lip dryness applied hyaluronic acid lipstick three times a day for a month. Results showed instant and long-term effects improving texture, definition, scaling, cupping, wrinkles, plumpness, and overall lip condition.

Cushiony and skincare-infused, the No Makeup Lipstick promises to give you the same results. It moisturizes, protects, and gives your lips a pop of color. Plus, it visibly improves lip firmness, smoothness, and definition.

In this formula, neuropeptides fight off sagging, while hyaluronic acid is the agent behind lasting hydration. Although it may be gentle enough on your skin, it contains advanced SPF Protection to shield you from sun damage.

Overall, the No Makeup Lipstick is a great option for anyone serious about their lips. It is available for $30.

Perricone MD No Makeup Blush Review

No Makeup Blush gives your cheeks a natural flush. If your skin is looking a little sullen or pale in the winter months, apply some of this to look alive again. The buildable coverage gives you the freedom to create a glow as subtle or prominent as you wish. 

This gel-cream blends easily and stays on all day, more forgiving on wrinkles than powder blush. Vitamin C ester and Chinese ginger plant extract work together and form a smooth antioxidant experience for your skin. Although evidence is still limited, a literature review[3] describes that topical application of vitamin C has anti-aging, anti-pigmentary, and photoprotective effects.

Perricone MD Vitamin C Ester Brightening Serum Review

Some skincare products promise a never-ending list of amazing benefits at the price of terribly pungent formulas. We pinch our noses when applying these potions, making the sacrifice. Thankfully, the Vitamin C Ester Brightening Serum is neutral—some users even love the scent!

Plus, it stands up to its tall claims of enhancing natural radiance and smoothing out texture. The potent Vitamin C serum is mixed with squalene and rosemary leaf extracts to shrink your pores and wake up your skin.

It’s widely known that vitamin c stimulates the synthesis of collagen. However, when applied topically, it cannot penetrate the epidermal barrier. A recently published study[4] combined vitamin C with squalane (a skin lipid). Compared to other vitamin C formulas, their preparation achieved way better skin penetration and significantly increased collagen production.

This Perricone MD review recommends applying a hyaluronic acid-packed lotion after using the serum.

You can purchase Vitamin C Ester Brightening Serum on the Perricone MD website for $69.

Perricone MD High Potency Classics Firming Eye Lift Review

The High Potency Classics Firming Eye Lift is driven to improve one thing…You probably guessed it: lifting and firming the delicate skin around your eyes. It won’t produce dramatic results right away; eye creams are more effective when incorporated into your nighttime routine and used diligently. 

You’ll observe shrinking crow’s feet and decreased puffiness in a day or two. Dark circles take a little more time to dissipate. Through a formula reliant on hyaluronic acid, DMAE, and squalane, the High Potency Classics Firming Eye Lift goes on smoothly and absorbs quickly into the skin

Hyaluronic acid is a component of the extracellular matrix with water retention capacity. As described in a review article[5], hyaluronic acid dramatically decreases in aged skin resulting in loss of skin moisture. DMAE is a precursor of the neurotransmitter acetylcholine. In a literature review[6] about the skin reparative properties of DMAE, the authors concluded that it increases skin firmness and may have anti-inflammatory activity.

You can buy the High Potency Classics Firming Eye Lift now for $72..

Perricone MD High Potency Growth Factor Firming & Lifting Serum Review

The High Potency Growth Factor Firming & Lifting Serum is a powerful way to give skin that coveted plump, bouncy look, but also develop its resilience against the effects of aging. Special Encapsulated Retinol technology means it may feel gritty at first, but don’t be alarmed. This is intended, so that the retinol can be soaked into your skin more easily and support its moisture barrier.

The anti-aging efficacy of retinol has been demonstrated in several studies. A review[7] published in the American Journal of Clinical Dermatology found substantial evidence regarding topical retinoids in the treatment of photoaged skin. Retinol improves the overall appearance of the aged skin by reducing wrinkles, inelasticity, pigmentation, and roughness. Common side effects[8] include skin irritation, redness, and skin desquamation (peeling). It is not recommended to use retinoids during pregnancy.

When it comes back in stock, High Potency Growth Factor Firming & Lifting Serum will be available for $129. This is the perfect time to sign up for Perricone MD’s newsletter, so you’ll be the first to grab this in-demand serum when it’s back. 

Perricone MD Neuropeptide Firming Moisturizer Review

This Perricone MD moisturizer is the real deal. It effectively helps restore the elasticity of thin, frail skin through deep hydration.

Ultra-powerful and creamy, the Neuropeptide Firming Moisturizer provides all-day softness. The formula contains phosphatidylcholine, which is a major component in human skin cells. When applied topically, it increases skin hydration[9].  Apply a small amount under makeup or after using Perricone MD’s Vitamin C Ester Brightening serum.

Its promise is a younger-looking complexion and intensive firming. Neuropeptide Firming Moisturizer is the culmination of twenty years of research and the most advanced firming moisturizer that Perricone MD has to offer—which is why it costs an eye-popping $290.

Perricone MD Cold Plasma Review

Based on Vitamin C Ester, Omegas 3, 6 & 9, and Copper Tripeptide, the Cold Plasma+ Advanced Serum Concentrate is an advanced remedy that promotes supple skin. All at once, it heals dullness, redness, large pores, deep creases, and more. 

Although there is little evidence, a nutraceuticals review[10] published in Dermatology and Therapy highlights that omega fatty acids have anti-inflammatory properties in the skin. At the same time, copper induces collagen synthesis and may have skin anti-aging, anti-inflammatory, antibacterial, and wound-healing effects.

Coming in at a one-time purchase of $149 the Cold Plasma+ Advanced Serum is a multi-tasking product that doesn’t skimp on any of the benefits. For results that will win compliments at the next social gathering, combine this serum with Perricone MD’s Cold Plasma Plus+Sub-D/Neck, which we’ll get into next. 

Perricone MD Cold Plasma Plus+ Sub-D/Neck Review

Cold Plasma Plus+ Sub-D/Neck is one of Perricone’s most established neck treatments. It is designed to slow the signs of aging and give a sculpted jawline, keeping everything taut and graceful. In an 8-week clinical study, 85% of people had improved skin elasticity, while 76% noticed redness disappearing.

Cold Plasma Plus+ Sub-D/Neck has a formula packed with DMAE for firming, peptides for fortifying against damage, and an all-natural skin tightening stimulant. This Perricone MD review is impressed by the courage of one customer who gifted this cream to her older sister. Let your actions speak louder than words for $135

Perricone MD Cold Plasma Plus Duo Review

Perricone MD Cold Plasma Plus+ Duo Review
Perricone MD Cold Plasma Plus+ Duo

Makeup can temporarily veil blemishes and sallow complexions. Eventually, long term neglect will start to shine through, always holding you back. To combat recurring skin problems at a more foundational level, bring Cold Plasma Plus+ Duo into your skincare regime.

Cold Plasma Plus+ Duo penetrates deep to correct damage and discoloration for a more polished look. After achieving velvet-smooth skin, you might even be compelled to toss out those full-coverage concealers. 

This fragrance-free product is also marked down to $199 from $259.

Perricone MD Reviews: What Do Customers Think?

Perricone MD Review

Is Perricone a good product?  The brand received an average of 4/5 stars on their website, with very few outliers.

One 5-star review for the Cold Plasma Plus Duo+ shared that it was compatible with mature, sensitive skin. She echoed the sentiments of many, in saying that Perricone MD’s moisturizers are best paired with some of their more drying serums. Her testimonial reads: 

“I have fair, sensitive and aging skin and harsh chemicals send me to the emergency room.  That is why Perricone MD’s Cold Plasma products are right for me.  I use them twice a day on my face and eyes after serum or toner for good, thorough coverage to lock in moisture.  A finishing cream with sun protection or a moisturizing cream is the final step.”

On Sephora, Perricone customers are in love and gave the brand a 4/5 star average from thousands of reviews. A buyer left this Perricone MD Face Finishing Moisturizer review: “This cream is SO good and left my skin looking younger and healthier almost instantly!! but I had to give it four stars because it made me break out SO much.”

On Trustpilot, Perricone MD received 4.6 stars out of 5. And while all the positive feedback from customers is reassuring, there were some common gripes amongst shoppers. For the most part, reviewers claimed that products were too expensive to repurchase, but most agreed that they saw satisfying results.

Is Perricone MD Worth It?

Perricone MD Review

This Perricone MD review can tentatively say that the brand is worth it. They have great customer reviews overall, a huge selection of products that treat multiple skin issues, and they use clinically-proven ingredients to promote healthier looking skin.

That said, Perricone’s recent acquisition by The Hut Group has left many customers disappointed in the recent changes to their favorite formulas. To be sure, customers still regularly leave 5-star reviews, but some of their fanbase has started to drift away.

As a result, we recommend keeping up with news of the brand before you decide to make a purchase. Take a look at your favorite formulas as well to observe any changes before pressing “add to cart”!

Perricone MD Promotions & Discounts

Perricone MD Review

This Perricone MD review sleuthed out many discounts for readers. For starters, customers can always take advantage of the Auto Replenishment subscription to save a few more dollars. The program is risk-free; you can cancel at any time. 

Additionally, the brand is offering a free full-size Cold Plasma Plus+ gift with purchase of The Intensive Hydrating Complex.  We also found more standard discounts:

  • 15% off initial orders
  • 30% off recurring orders of No Makeup products under their skincare line 
  • 40% off recurring orders of Supplements and Acne Relief

In terms of promotion codes, these are time-sensitive ones currently advertised on their website: 

  • With the code NMSEVENTNMSEVENT, you’ll save 40–50% on their No Makeup Skincare Event
  • Celebrate Mom sale for 25% off gift sets. Use the code FORMOM to activate your savings.

There’s more—this Perricone MD review isn’t done listing the discounts yet! SiriusXM listeners get $50 off orders $125 and more with code RADIO (available until the end of June 2021)—and anyone who spends $125+ at checkout can select their own gift

While we’re not entirely sure what the gift exactly entails, it’s clear that students (who verify their status and register) get a special 50% discount through Perricone MD’s program, “Student Beans”.

Perricone MD warehouse sales may also be available from time to time, so sign up as a member and keep an eye on your email inbox.

Where to Buy Perricone MD

Perricone MD Review

Perricone MD is available to buy on their website: Their products are also available at a number of retailers such as: 

  • Amazon
  • Walmart
  • Sephora
  • Look Fantastic
  • Skinstore
  • Ulta Beauty
  • Nordstrom


Perricone MD Review

Who owns Perricone skincare?

This Perricone MD review was surprised to find that Perricone skincare is owned by The Hut Group, which acquired it for $60 million in 2020. The Hut Group was founded by British businessman Matthew Moulding and owns many cosmetics and personal care brands.

Is Perricone MD a clean brand?

This Perricone MD review can confidently report that it is a clean brand. Their products are safe, award-winning, and effective for treating a wide assortment of dermal complications. The Perricone diet and their supplements are additional ways for customers to strengthen their skin and body.

Does Perricone MD have retinol?

Some Perricone MD serums have retinol. It is a critical and highly recommended ingredient for promoting collagen development, decreasing acne and hyperpigmentation.

Is Perricone MD all natural?

No, Perricone MD is not all-natural. While their products do contain many natural ingredients, some also include clinical-level acids and formulas to address long-standing skin issues.

Is Perricone MD good for acne?

Perricone MD has a whole category of products dedicated to getting rid of acne. Their simple two-step skincare system works with your skin to improve acne issues.

Is Perricone MD good for sensitive skin?

It absolutely is. As far as Perricone MD reviews go, customers reported great effects on sensitive and mature skin, and some items in their wide range of products were specifically designed for this issue.

How do I know when my Perricone MD expires?

Most Perricone MD products, like Perricone MD Blue Plasma, come with an expiration date. Be sure to carefully check your packaging and the bottle itself to find how long it will be effective.

What is Perricone MD’s Shipping Policy?

Perricone MD offers free standard shipping on orders $75 or over. Read the short guide below for more details on Perricone MD‘s shipping policy.

US Standard Shipping

  • Arrives within 7–9 business days
  • Costs $6 for orders under $75
  • Orders over $75 are free

US Express Shipping

  • Arrives within 2–3 business days
  • Charges $10 for orders of any amount
  • Order before 4 PM CST

US Premium Shipping

  • Arrives within 1–2 business days
  • Costs $20 for orders of any amount
  • Order before 4 PM CST

International Delivery

  • Delivery expected within 10–14 business days
  • Orders must be 4.4lbs or under
  • Shipping costs $15 for orders of any amount
  • Deliveries outside the US could result in import duties and taxes (including VAT)

What is the Perricone MD Returns Policy?

This Perricone MD review has a simple guide to making a return. Note, only damaged, faulty, or unopened items can be returned for a refund. 

Follow the steps provided below for a successful return:

1. Prepare your order number, which can be found in your order confirmation email

2. Prepare photographic evidence of damaged or faulty items, if applicable

3. Login to your Perricone MD account and message customer support by email or live chat

4. Talk to one of Perricone MD’s advisors

5. Receive a Returns Authorization Number

6. If the return request is accepted for a damaged or faulty item, a pre-paid returns label will be sent to your email address

7. Print the pre-paid returns label and attach it to your package

8. Mail your items back to Perricone MD

9. Receive your refund within 14 days of the return package being received

How to Contact Perricone MD Customer Service

Perricone MD‘s Live Chat support function is currently not working, so customers have three options: 

  • Call customer service: 888-823-7837 (Monday–Friday, between 9AM and 6PM ET
  • Sign in to your Perricone MD account and send a message

Send them a direct message on Facebook, Twitter, or Instagram

We know how important skincare is! Check out our reviews for other top skincare brands:

Versed Skin

Black Wolf Nation

True Botanicals

Tiege Hanley

Article Sources

[1] Coupland, J. Ageist Ideology and Discourses of Control in Skincare Product Marketing Springer Link In Discourse, the body, and identity (pp. 127-150). Palgrave Macmillan, London
[2] Makino, E. T., Tan, P., Qian, K., Babcock, M., & Mehta, R. C. Clinical Assessment of Immediate and Long-Term Effects of a Two-Step Topical Hyaluronic Acid Lip Treatment Journal of drugs in dermatology : JDD, 16(4), 366–371
[3] Al-Niaimi, F., & Chiang, N. Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications The Journal of clinical and aesthetic dermatology, 10(7), 14–17
[4] Gref, R., Deloménie, C., Maksimenko, A., Gouadon, E., Percoco, G., Lati, E., ... & Couvreur, P. Vitamin C–squalene bioconjugate promotes epidermal thickening and collagen production in human skin Scientific reports, 10(1), 1-12
[5] Papakonstantinou, E., Roth, M., & Karakiulakis, G. Hyaluronic acid: A key molecule in skin aging Dermato-endocrinology, 4(3), 253-258
[6] Grossman, R. The Role of Dimethylaminoethanol in Cosmetic Dermatology American journal of clinical dermatology, 6(1), 39-47
[7] Riahi, R. R., Bush, A. E., & Cohen, P. R. Topical Retinoids: Therapeutic Mechanisms in the Treatment of Photodamaged Skin Springer Link American journal of clinical dermatology, 17(3), 265-276
[8] Kang, H. Y., Valerio, L., Bahadoran, P., & Ortonne, J. P. The Role of Topical Retinoids in the Treatment of Pigmentary Disorders Springer Link American journal of clinical dermatology, 10(4), 251-260
[9] Ghyczy, M., & Vacata, V. Phosphatidylcholine and Skin Hydration In Skin moisturization (pp. 327-346). CRC Press
[10] Souyoul, S. A., Saussy, K. P., & Lupo, M. P. Nutraceuticals: A Review Springer Link Dermatology and Therapy, 8(1), 5-16

Ask the community or leave a comment

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About my account
Asked by Carime Quezada (2 years ago) Reply

They overcharged me

Answered by Carime Quezada (2 years ago) Reply

I was overcharged

Extremely Dissatisfied
Asked by Elizabeth Melanz (2 years ago) Reply

I used the Growth Factor Firming and Liftimg Serum and Brightening Serum for approximately six months. During that time I saw no visible results, therefore I let it go. I tried other products from The Ordinary and some results within two weeks. Decreased dark spots, brighter and firmer feeling. And at major fraction of the cost. Major lesson learned, brand name and price does not equal results. What was promoted/promised from this high end brand definitely did not deliver!

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