Best Lion’s Mane Supplements

Searching For the Best Lion’s Mane Supplements

Best Lion’s Mane Supplements

Lion’s mane has recently gained tons of prominence as a powerful nootropic supplement. These mushrooms are said to be able to help slow down aging, improve focus, and reduce inflammation.

The lion’s mane variety of mushrooms are high in anti-inflammatory and antioxidant properties that have immune-boosting capabilities, proven to lower the risk of diseases associated with the heart and specific cancers.

“Lion’s mane could protect against dementia. This is because Lion’s mane has compounds named hericenones and erinacines, which both stimulate the growth of brain cells,” said Bill Bradley, a registered dietician.

Meet the Expert: Bill Bradley, RD

Bill Bradley, RD, has been teaching and writing about Mediterranean diet and lifestyle for the past 10 years. Recently, Bill spent time on the Mediterranean island of Crete researching the traditional cuisine and co-writing Foods of Crete, Traditional Recipes from the Healthiest People in the World.

Bill has led over 1600 talks and cooking workshops; has been featured on ABC News on-line, various newspapers, magazines, and talk shows; and has authored two cookbooks.

Additionally, lion’s mane has also been proven to protect against neurodegenerative diseases and to reduce mild symptoms of anxiety and depression by repairing nerve damage, as this study shows.

However, these benefits are nothing new. Lion’s mane mushrooms and their extracts have long been used by both traditional Chinese and Japanese herbalists. It’s easy to walk into any small Chinese herb shop and find buckets of dried lion’s mane mushrooms.

However, the mushroom’s benefits are best absorbed in their extract form through supplements. That’s why we’ve assembled a list of the best lions mane supplements available today. I’ll talk about what each one does, give a bit of their brand’s backstory, and fill you in on some other crucial details.

I’ll also let you know some tricks to help you decide which of these supplements is best for your particular set of skills and needs. There’s a solution for every problem, but sometimes the problem is just finding the correct solution. 

Without further ado, let’s dive into the world of lions and fungi (and bears, oh my!).

8 Best Lion’s Mane Supplements

1. Rainbo Lion’s Mane Brain Power Super Mushroom Tincture

Rainbo Lion's Mane Brain Power Super Mushroom Tincture

If I’m going to write about the best lion’s mane supplements then I should begin with a brand that is positively addicted to mushrooms.

What I mean is that Rainbo is a company that specializes in mushroom-based supplements. They believe that fungi are some of the most beneficial compounds on Earth. With that in mind, they seek to maximize every available mushroom’s bioavailability by extracting them and integrating them into simple supplements.

The Rainbo Lion’s Mane Brain Power Super Mushroom Tincture is a perfect example of this plan. The Canadian-based company’s lion’s mane supplement can be taken every day to support mental health and protect against aging.

Tinctures are highly concentrated herbal extracts that are swallowed or absorbed under the tongue. This study shows the beneficial components of tinctures, revealing that all homemade tinctures exhibit strong antioxidant properties.

It, like many of the items on this best lion’s mane supplements list, is a nootropic, a drug designed to improve brain functioning. The Rainbo Lion’s Mane Brain Power Super Mushroom Tincture can boost your mood, keep your memory sharp, and improve your focus.

An 8.4 fl oz bottle of Rainbo Lion’s Mane Brain Power Super Mushroom Tincture costs $40

2. Host Defense Lion’s Mane Capsules

Host Defense Lion’s Mane Capsules
Host Defense Lion’s Mane Capsules

Host Defense calls the Olympic Rainforest in Washington home, which partially explains why they’re the best-selling mushroom supplement brand in America.

But best-selling doesn’t always mean the highest quality (I’m looking at you, Back in Black). Thankfully, Host Defense Lion’s Mane Capsules is one of the best lion’s mane supplements on the market, so you’re in no danger of being swindled. 

The brand was founded by noted mycologist Paul Stamets as a way to connect customers with the enchanting fungal world. Doing so would only bring about favorable results, both for buyers’ health and for the environment. That’s because Host Defense controls every aspect of their manufacturing process.

They grow all their own mushrooms, test them like they’re students trying to qualify for law school, and continue to conduct their own research on the magical health benefits of mushrooms. 

Some supplements can help you get enough of the vital substances your body needs to function at its best, and others may help reduce the risk of disease. This review concluded that in the long run, supplements have been suggested to slightly increase the risk of cancer and cardiovascular diseases.

However, in the short run they produce little harm or no harm, so there should be no negative consequences for individuals taking them. 

Speaking of benefits, let’s cover what the Host Defense Lion’s Mane Capsules can do for you. Here’s a quick list of their purported effects:

  1. Optimize cognitive awareness
  2. Embolden focus
  3. Back up your nervous system

You can collect 30 Host Defense Lion’s Mane Capsules for $15, which is a discount on its regular market price of $20.

The brand recommends taking two capsules a day. If you’d prefer to bulk the product in bulk they also have these options:

  • 60 Host Defense Lion’s Mane Capsules: $24 (regular price, $32)
  • 120 Host Defense Lion’s Mane Capsules: $45 (regular price, $60)

3. Noomadic Lion’s Mane Mushroom Capsules

Noomadic Lion’s Mane Mushroom Capsules
Noomadic Lion’s Mane Mushroom Capsules

Much like a cool bouncer at a metal bar who’s sick of seeing posers flaunting their stuff, Noomadic is a company that’s tired of performative fluff. They want to form a space in the supplement industry for safe, filler-free products that customers can trust.

That’s why the brand only uses the purest extracts possible in all their products. I respect Noomadic’s dedication to purity, but I love their Noomadic Lion’s Mane Mushroom Capsules even more.

It seems that internet users also believe the item is one of the best lion’s mane supplements currently available. They gave it enough high reviews that the product holds an average rating 5/5 stars from more than 30 pieces of customer feedback on the Noomadic website.

Many of the customers linked the product to these noticeable improvements in their daily lives:

  • More clarity in their thoughts and actions
  • A stronger immune system
  • Helping blunt the worst aspects of their depression
  • Easier to maintain a calm state of mind

That’s not all the Noomadic Lion’s Mane Mushroom Capsules claim to do. These supplements can give you the memory of an elephant especially when it comes to short-term and visual recognition memory.

It’s of little shock but plenty of awe that these capsules are among Noomadic’s best-selling products. Just goes to show how much integrity resonates with customers. I’m glad Noomadic doesn’t tolerate posers and works to create one of the best lion’s mane supplements.

You can test this item out for yourself by grabbing a bottle of Noomadic Lion’s Mane Mushroom Capsules for $30. Each bottle contains 60 capsules. The brand advises customers to take 1 to 2 capsules two times a day for best results.

4. Centred. Organic Lion’s Mane Mushroom Extract 

Centred. Organic Lion’s Mane Mushroom Extract 
Centred. Organic Lion’s Mane Mushroom Extract 

The Centred. Organic Lion’s Mane Mushroom Extract qualifies for our list of the best lion’s mane supplements because it’s informed by the company’s rigorous development process.

The young company actually specializes in hair care. They were founded by former fashion industry worker Laura Tudor and hairdresser Kieran Tudor in 2017. However, they take the care necessary to succeed in both of those industries and apply it to their product development.

That means they consider how they can create sustainable products that promote wellness just as effectively. They do so by using bottles made from 100% post-consumer recyclables, sourcing all their vegan ingredients from cruelty-free suppliers, and keeping their labor as local as possible.

You could say they’re centered on overall health (bad pun, I apologize). What’s so great about Centred. Organic Lion’s Mane Mushroom Extract is that you can see the level of care in it.

Customers felt that consideration too, obvious by the glowing reviews they left on Centred.’s website. One customer said, “I’ve been taking tablets for over a week now and already I feel more focused and my memory feels clearer.

Beyond that, this lion’s mane supplement can have a positive effect on your mood too. It can be what you need to add some spring to your step. 

You can grab a box of Centred. Organic Lion’s Mane Mushroom Extract for $39. Inside each box are 60 all-natural capsules.

Centred. advises customers to take between 2 to 4 capsules every day, usually with a meal.

5. Harmonic Arts Lion’s Mane Concentrated Mushroom Powder

Harmonic Arts Lion's Mane Concentrated Mushroom Powder
Harmonic Arts Lion’s Mane Concentrated Mushroom Powder

Although the Vancouver Island-based supplement company describes themselves as small, they’re certainly mighty. They’ve kept their operations tight within their herbalist family since 2009, allowing them to stick to their mission of improving people’s health with plant power.

They are so confident in their practices that Harmonic Arts publishes their yearly impact record on their website. They are transparent in their practices so that you can feel certain that you’re fueling your body intelligently.

Speaking of intelligence, the Harmonic Arts Lion’s Mane Concentrated Mushroom Powder might be your ticket to a higher form of thinking. The powder can boost cognitive functioning, keep your memory and focus whip-snapping, and preserve nervous system functioning even as you age.

This is one of the best lion’s mane supplements because it comes in a powder as opposed to a capsule. That makes it a great ingredient in smoothies, yogurts, and coffee. Harmonic Arts provide some outside-the-box applications too, like throwing it into a boiling soup stock or mixing it in with your salad dressings.

That ingenuity makes us want to see what I could craft up using this mushroom powder. Sadly, there are no reports as to whether it’ll add to a dish’s umami flavor, so I’ll have to stick to our trusted monosodium glutamate in the meantime.

The Harmonic Arts Lion’s Mane Concentrated Mushroom Powder has wowed customers. It scores 5/5 stars from 9 customer reviews on the brand’s website.

These reviews tout the product as being helpful to ease migraines as well as possessing a high potency.

45g of Harmonic Arts Lion’s Mane Concentrated Mushroom Powder could be in your hands for $21, though it’s regularly priced at $25. If you want more of this sweet fungal powder then you can purchase 100g for $36. That’s a 14% discount on that product’s normal cost of $45.

6. Double Wood Supplements Lion’s Mane Mushroom Capsules

Double Wood Supplements Lion’s Mane Mushroom Capsules
Double Wood Supplements Lion’s Mane Mushroom Capsules

Double Wood Supplements aims to be a double threat in the nourishment industry. Not only do they produce some of the best dietary supplements you can get, but they’re also committed to teaching their customers about the inner workings of the diet market.

That’s why their website is loaded with informational blog posts that dispel the science from the pseudo-science. Thankfully, they’re more than a bunch of nitpicking debate club nerds. The  Double Wood Supplements Lion’s Mane Mushroom Capsules shows that this brand wants to lead by example by delivering a top-notch product above all else.

How can one product epitomize an entire brand’s approach? It’s not difficult when it’s one of the best in its class in certifications, tests, and customer reviews.

For the first two points, Double Wood Supplements proudly displays the certifications and tests their lion’s mane product has earned and passed. It’s been viciously tested by third-party researchers and seems to have sent them flying back in their chairs.

It’s safe to assume that customers had to take a seat too with how much energy they put behind their reviews. This 5-star reviewer wrote, “I have been using this product for over a year. Thanks to a bad car accident I have nerve damage in my arms and legs. I use this supplement daily and it is the only thing that helps with the severe nerve pain.

That’s only one of the 16 5-star reviews customers left on the company’s website. 

If you want to see what all the hype is about then you should consider picking up 120 Double Wood Supplements Lion’s Mane Mushroom Capsules for $19. Each capsule contains 500mg of that good mushroom mojo.

7. Om Lion’s Mane Mushroom Capsules

Om Lion’s Mane Mushroom Capsules
Om Lion’s Mane Mushroom Capsules

What do you get when you cross a preventative medicine Ph.D. holder, a mycologist with over three decades in the field, and a dream to better mankind through mushrooms? You get Om, the California-based brand that has a whopper of a lion’s mane supplement.

Both founders are experts in their respective medicine and mycology fields, meaning that the company is built on a foundation of science. Furthermore, they use that science to deepen the bonds between people by making everyone healthier.

Om Lion’s Mane Mushroom Capsules are one of the few lion’s mane products that specifically state that it can boost creativity alongside the vast slew of other benefits the mushrooms impart. 

Normally, people have to expand their consciousness through other, less reality-bound means, so it’s great to learn that Om Lion’s Mane Mushroom Capsules can offer a way to flex your creative muscle. Another study supports previous findings that increased intake of the mushroom has the possibility to reduce depression and anxiety.

Customers who used this product reported that they stuck with it for years because of the effects they noticed after beginning a daily regimen. Others developed an interest in it to offset any adverse aging-related brain effects and found the supplement delivered what they were looking for.

One customer used it for a cause I hadn’t seen throughout our entire research. She said, “I’ve been using Lion’s mane mushroom capsules for menopause-related brain fog for about 5 months now. I love them!

Overall, Om Lion’s Mane Mushroom Capsules garnered a 4.6/5 stars average from more than 30 customer reviews on the brand’s website.

If you’re looking to see how you can ail your menopause woes or voids of creativity, then check out this item for $35. One order will get you 60 servings, and if you’re taking the recommended daily dosage, it should last you around two months. 

8. Real Mushrooms Organic Lion’s Mane Extract Capsules

Real Mushrooms Organic Lion’s Mane Extract Capsules
Real Mushrooms Organic Lion’s Mane Extract Capsules

Real Mushrooms hold tightly onto their name. Their products are fully pure and organic. You won’t get anything else but mushrooms with these cats. They won’t play around, tease you with faulty non-medicinal ingredients, or pretend that a portobello could ever replace a sirloin steak.

They know what mushrooms can do for your health, and they’re here to serve that to you in the form of Real Mushrooms Organic Lion’s Mane Extract Capsules

They don’t have patience for fake mushrooms. They would slap that mushroom bouillon powder out of your hand if they saw you making soup with it. Instead, they’d offer you something you could really sink your teeth into, like their mushroom chocolate bars.

But I’m not here to tell you about this. That’s what google is for. I’m here to tell you why Real Mushrooms makes one of the best lion’s mane supplements.

Let’s start with the fact that each 500mg capsule contains enough lion’s mane extract that you might turn into a mushroom yourself. Wouldn’t that be funky? 

That’s not the only funk this plucky brand offers. There’s no additional starch or wheat in any of these capsules, meaning you’re only ingesting pure lion’s mane extract

These puppies are so pure even your dog could take them. I’m not joking either. Veterinarians recommend Real Mushrooms Organic Lion’s Mane Extract Capsules for dogs who are feeling under the weather too.

Ask yourself, if you would feed your dog a supplement, would you take it yourself? That answer should be yes, cause you should always trust your best friend. You know how the old saying goes.

If you want a whiff of this 5/5-star product, based on over 425 customer reviews on the brand’s website, then gobble up a bottle of 120 Real Mushrooms Organic Lion’s Mane Extract Capsules for $30.

What Does Lion’s Mane Do For the Body? 

Best Lion’s Mane Supplements

Wouldn’t it be delightful if instead of passing a joint around the party while the newest Action Bronson mixtape soundtracked the occasion, today’s youth shuffled a communal cauldron of lion’s mane mushrooms between their hands?

Imagine if you were in that rotation. Your friend Rory, who you’ve known most of your life and has a commemorative tattoo of Jose Bautista’s notorious bat flip, passes you the bowl and says, “bro you gotta hit this, it’ll protect your lower intestines from ulcers.”

I can only dream. What I don’t have to dream about is that lion’s mane could potentially stop ulcer-causing bacteria from growing in your digestive tract. Plus, it could help strengthen our stomachs’ linings.

This study concluded that the aqueous extract of lion’s mane mushroom has protective effects of the mastric wall against injuries. The protection was shown to be dose dependent for the reduction of ulcer areas in the gastric wall and the reduction or inhibition of infiltration of submucosal layers.

The best lion’s mane supplements could also potentially be great heart disease preventatives. Studies have found that the supplement was associated with lower triglyceride counts in lab mice. 

Finally, and perhaps most importantly given how little I still understand about how to combat the disease, lion’s mane was able to kill off cancer cells in test tubes.

This leads our article writers to believe that the supplement may be beneficial for those with cancer, though it should be taken alongside a doctor-recommended cancer treatment plan.

What Does Lion’s Mane Do to the Brain? 

Best Lion’s Mane Supplements

Lion’s mane’s mental benefits are due to the roles of two of its ingredients, hericenones and erinacines. These compounds have been linked with higher levels of brain cell growth

The best lion’s mane supplements are often advertised as anti-aging supplements because they can help promote brain cell development later in life even as our brains stagnate.

Being old is great. Being old and dumb is not.

So lion’s mane could be useful to offset mental degradation due to aging and potentially protect against dementia. Additionally, the supplement has been to lower levels of depression and anxiety in rats.

That’s because lion’s mane has anti-inflammatory properties, meaning it could potentially dampen brain swelling. Mental illnesses like depression and anxiety are often found in those with inflamed brains, so deductive reasoning insinuates that lion’s mane could be useful for those suffering from the aforementioned illnesses. 

Can You Take Lion’s Mane Everyday? 

Best Lion’s Mane Supplements

Here’s the good news: if you love mushrooms, then you’re safe to consume lion’s mane every day. Heck, it’s safe to take the supplement every day even if you don’t love mushrooms.

According to Bradley, “Lion’s mane is safe to take every day. However, there’s no consensus that states how much Lion’s mane can be taken per day. Daily doses of 250 mg to 500 mg are deemed effective in some studies.”

Some studies researched the effects of taking 750mg of lion’s mane daily for over four months and found no adverse side effects

Lion’s mane is a mushroom after all, so it’s not like anyone has ever put their lives in danger by consuming any mushroom variant on a daily basis. Nope, none, not even the psychedelic types your Uncle Fester grew in the back of his Winnebago as a way to make ends meet.

I’m kidding! You can relax though, lion’s mane mushrooms have no relation to psychotropic mushroom strains. That’s why most of the best lion’s mane supplements distill the fungi into powder or a pill. They crush it down to concentrate its health benefits.

So you could just eat pounds of lion’s mane mushrooms every day. I’ve done that before by accident and the only side effect I felt was a satisfied tummy and a little less stomach space for dessert.

In fairness, studies have reported some side effects from lion’s mane supplements, but only in those who were allergic to mushrooms. The observed side effects were all allergic reactions to mushrooms, leading professionals to believe that, although lion’s mane by itself is safe, people with mushroom allergies would be better off finding an alternative supplement. 

How to Choose the Best Lion’s Mane Supplements

Best Lion’s Mane Supplements

With all the best lion’s mane supplements covered, it’s time I told you some strategies you can implement to help you decide which of them is best for you.


Never buy into a brand’s pretty marketing, not unless you can see what the customers have to say. All the brands I’ve included in this listicle sit at the pinnacle of the supplement industry, so I doubt you’d go wrong with any of them. However, a little extra research can go a long way.


The supplement market is as diluted with non-active ingredients as a Discord group chat is littered with non-active participants. That’s why it’s important to check which ingredients are actually in your supplements.

Thankfully, the lion’s share of the best lion’s mane supplements producers is transparent with their ingredients. They majorly use only the necessary ingredients and cut out the unnecessary fluff.


You could buy the best lion’s mane extract on the market that would heal you of any potential health crises, but it’d be worth nothing if you only got enough for one day’s dosage.

That’s why it’s crucial to look at how much you’ll be getting with each supplement. You should look at what the daily recommended amount is, how much extract each capsule contains, and how long a single purchase will last you based on your needs. 

Health Condition

As I touched upon in a previous section of our best lion’s mane supplements list, the only people who should be wary of these powerful fungi are people who already fear the fungal kingdom due to allergies.

Doctors and researchers have yet to discover any adverse effects coming from lion’s mane supplements except in people who suffer from mushroom allergies. 

Forgive us for being pedantic, but duh. In the same way that cashews aren’t healthy for people with nut allergies, lion’s mane can’t be considered a healthy supplement if mushrooms inflame your oral cavity and cause you to hallucinate.

If that’s not you, then disregard that consideration. Dive deep into the lion’s mane jungle! Make Mufasa proud.

Final Thoughts

Best Lion’s Mane Supplements

Looking back at this list of the best-in-class lion’s mane supplements, I’m proud of what each and every entry offers. All these companies seem to have the customers in mind first, with their environmental impact narrowly trailing behind. 

That fills our hearts with joy. It’s good to know that the best brands for one’s health are oftentimes those that are the most considered with the health of the world we all inhabit. With that being said, it’d be hard to go wrong with any of the lion’s mane products I listed today.

Looking for other top brands? Check out these curated lists below:

10 Best Sock Brands

10 Best Eyewear Brands

8 Best Collagen Brands for Hair Growth

10 Best Wholefood Multivitamin Brands

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