Bio X4 Review

About Bio X4

Bio X4 Review

Bio X4 is a nutritional supplement designed to improve digestion, control unhealthy cravings, and help you manage your weight.

Made up of four curated ingredient blends, this supplement might just be a great new addition to your daily health regime.

This supplement has been gaining a lot of media attention in recent years. Their parent brand, Nucific, has garnered 61.7k Instagram followers and over 508k followers on Facebook.

Plus, they’ve been featured in New York Magazine, PRNewswire, and more. 

If you’re looking for a supplement to help improve your digestive health and manage your weight, look no further than this Bio X4 review.

I’ll walk you through the brand’s story, the details of this product, reviews from customers who’ve tried it out, and more to help you decide if it’s worth pulling out your credit card for. 

Overview of Nucific

Bio X4 Review

Nucific was founded by Dr. Amy Lee in 2014. Dr. Lee, who is a board-certified physician with the American Board of Internal Medicine and specializes in obesity medicine, was inspired to start the brand due to her desire to understand how food behaves inside the body. 

In Dr. Lee’s own words: “Here at Nucific, our goal is simple: To help you get the body and life you deserve. Our powerful formulas combine natural digestive enhancers with cutting-edge enzyme supporters — to help people at home manage their weight, improve their energy, and feel healthier overall.”

Nucific believes that nutrition is the key to a healthy body. And, although you should be eating your fruits and veggies, getting enough vitamins, and the like, sometimes a supplement can give you a much-needed extra boost. This is where Bio X4 comes in.

Before diving into the specifics of our Bio X4 review, I’ll take you through some key highlights:


  • Helps with weight management
  • Reduces cravings
  • Improves digestion
  • Increases energy levels
  • Thousands of positive reviews
  • Buy more, save more
  • 90-day money-back guarantee
Bio X4 Review

Although Nucific offers a number of nutritional supplements, this review will focus exclusively on one of their best-sellers, Bio X4. To see what it’s all about, read on! It could be the solution you’re looking for. 

Bio X4 Review

A lot of people struggle with their weight. Maybe you’ve found yourself spending hours in the gym and in the kitchen cooking healthy meals but can’t seem to lose those last few pounds. Or, maybe you’re just getting started on your weight loss journey and are looking for a kick-starter.

Health experts have estimated that about 11%[1] of the US population suffers from some sort of digestive disease, with this number jumping to 35% in people 65 and older. Aside from the obvious issues associated with digestive problems like bloating and stomach pain, poor digestion can contribute to issues with weight loss or gain.

Additionally, there are a significant number of people that don’t have a diagnosable disorder but regularly deal with bothersome digestive symptoms. One study[2] from 2019 found that, out of a sample of over 71,000 people, 61% of them reported having at least one gastrointestinal symptom in the previous week.

Even more, about 42% of American adults are considered obese. The combination of digestive symptoms and excess weight can be a recipe for discomfort and poor health. While a supplement on its own likely won’t be enough to turn things around, it can help get things started and give you an extra boost. This is where Bio X4 shines. 

This supplement claims to be able to manage cravings, help with weight management, improve digestion, and even increase your energy. How does one little pill accomplish all of this?

Well, it’s thanks to the four unique ingredient blends that the product contains. Below, I’ll take a deep dive into the list of Bio X4 ingredients and look at what it does for your health.

You can order 1 bottle of Bio X4 for $99, which is a 30-day supply. You can also order three bottles and get 12% off the total cost, or buy 6 bottles and save 18%!

Who Is Bio X4 For? 

Bio X4 Review

Bio X4 can be helpful for people suffering from bothersome digestive issues, as well as those who are looking to lose weight. You don’t need to have a diagnosed digestive disorder in order to benefit from this product. A majority of Americans deal with digestive symptoms but don’t have a disorder, so this product can help.

Similarly, you don’t need to necessarily be obese or overweight to reap the benefits of Bio X4. Perhaps you’ve recently lost weight and simply want to maintain it, or have always been at a healthy weight and want to keep up the good work.

Either way, Bio X4’s weight management blend, and craving control blend can help you out.

What Are the Benefits of Bio X4?

Bio X4 Review

Bio X4 offers a host of benefits related to digestion and weight management, including:

  • Better digestion
  • Fewer cravings
  • Improved weight management
  • More energy

How Does Bio X4 Work?

Bio X4 Review

Bio X4 works in four different ways, thanks to its four unique ingredient blends. The probiotic blend works to create a healthy gut environment, strengthening your digestive system.

Similarly, the digestive enzyme blend helps your body to break down starches, fats, and proteins, promoting better digestion. On the other hand, the weight management blend and craving control blend work together to help you reach or maintain a healthy weight.

What Are the Ingredients In the Bio X4?

Bio X4 Review

Bio X4 consists of four curated ingredient blends, including:

  1. Probiotic Blend: Probiotics[3] are good bacteria that create a healthy environment for the breakdown of food in your digestive system. This ingredient blend contains multiple lactobacillus and bifidobacterium strains.

One study[4] showed that IBS patients who consumed lactobacillus acidophilus (one of the strains in Bio X4) experienced a reduction in abdominal pain after 4 weeks.

Another study[5], which looked at a bifidobacterium strain, showed that it successfully improved immunity by increasing the capacity of immune cells in the digestive system.

  1. Digestive Enzyme Blend: Digestive enzymes are what help to properly break down food and ensure that you’re digesting things well. This blend contains the digestive enzymes amylase, bromelain, and lipase.

Amylase and lipase are naturally found in the body and help break down starches and fats, respectively, while bromelain helps to digest proteins. Bromelain comes from pineapple, and studies[6] have shown that it can help with diarrhea.

  1. Weight Management Blend: this blend contains only green tea extract, which is mighty enough on its own. One study[7] showed that women who consumed a high dose of green tea extract over 12 weeks experienced weight loss and a smaller waist, along with lower cholesterol levels.

Another study[8] showed that, along with weight loss, green tea helps to maintain weight loss.

  1. Craving Control Blend: Caralluma fimbriata extract is the solo star of this blend. This ingredient comes from an edible cactus. One study[9] showed that the extract appears to act as an appetite suppressant, helping with weight loss and management efforts

There you have it! This simple combination of four blends works together to provide you with a host of health benefits for your digestion and weight. Pick up a bottle and experience the positive effects for yourself.

Up next in our Bio X4 review will tell you how to take it.

How to Take Bio X4 and Dosage

Bio X4 Review

According to Nucific, you should take one capsule of Bio X4 three times a day, one with each meal. Each bottle contains 90 capsules, lasting 30 days.

Bio X4 Side Effects

Bio X4 Review

This review found no known Bio X4 side effects of this supplement. This is thanks to the pure ingredients in the capsules and the fact that they are gluten-free and allergen-free. However, you should talk to your doctor before starting any new supplements that could impact your health.

Bio X4 Reviews: What Do Customers Think?

Bio X4 Review

Bio X4 is a four-in-one daily supplement that claims to help to improve your digestion, manage your weight, and boost your energy levels. But does it deliver on these promises?

To find out, I scoured the internet to find Bio X4 reviews from customers to see if it lives up to the hype. I looked at the Nucific website and Amazon to find out. Here’s what they averaged:

  • Nucific: 4.6/5 stars from a total of 3,899 reviews
  • Amazon. 3.9/5 stars after 7,478 global ratings

One happy customer commented on the difference it made for both themselves and a loved one:

My wife and I are very impressed with this Nucific product. We both felt a difference in our bodies within the first week. My wife no longer is bothered by constipation. We both feel more energy and less bloating after a meal.” Most of the other reviews were along the same vein.

Those who were pleased with the product on Amazon commented on its positive effects on their digestion and weight loss benefits. One customer wrote:

Great product! Was having stomach trouble. Everything I ate would cause me to have stomach pain and diarrhea. After 2 weeks of taking this my system was back to normal and has been since.”

Another said: “I bought one bottle of this product as I am very skeptical. I take it twice a day with my 2 larger meals. It takes my appetite away and does not leave me feeling shaky. I am now on bottle #3 and down 30 pounds.”

Finally, I headed over to the Better Business Bureau website, where Bio X4’s parent brand, Nucific, was awarded a stellar A+ rating. The brand seems to be good at resolving customer complaints and ensuring that those who spend their money on Nucific’s products are satisfied.

Overall, Bio X4 seems to have positive customer reviews from multiple sources.

Is Bio X4 Worth It?

Bio X4 Review

Yes! I definitely think that Bio X4 is worth it, and that’s for a couple of reasons.

First, the product’s ingredients are backed by science. It’s easy for a company to sell snake oil and say it cures everything, but I did our own independent research and found that the ingredients do in fact help with what the company claims they help with.

Second, I like the fact that the product has thousands of positive customer reviews. This points to the fact that the product delivers on its promises for a majority of customers. 

Remember, everyone’s body is different, and what works for you might not work for someone else. But, this product seems to work well for most.

Bio X4 Promotions & Discounts 

Bio X4 Review

This Bio X4 review found that first-time customers can sign up to Nucific’s email list and receive a special offer on their first order. Plus, Nucific offers a buy more, save more option. You can purchase three bottles and save 11% of the total cost, or splurge for 6 bottles and save 18%

There were no other discounts on the brand’s website at the time that this Bio X4 review was written, but I did find that they offer discounts throughout the year on special holidays, so keep checking back on their website.

Where to Buy Bio X4

Bio X4 Review

Bio X4 can be purchased from Nucific, Amazon, and Gosupps.com.


Bio X4 Review

How many Bio X4 should I take daily?  

Nucific recommends taking three capsules of Bio X4 every day: one with each meal. However, you can take up to two capsules per meal if desired.

Should I take Bio X4 with food?  

Yes, Bio X4 should be taken at meals.

Is Bio X4 vegan?  

Bio X4 is not vegan. The probiotic strains in the supplement come from dairy.

Is Bio X4 gluten-free? 

Yes, Bio X4 is gluten-free.

What are the supplement facts of Bio X4? 

Bio X4 contains 4 billion CFU of probiotics per capsule. Additionally, each capsule contains 43mg total of the digestive enzyme blend, 100mg of green tea extract, and 166mg of caralluma fimbriata extract.

What is Nucific’s Shipping Policy?

When purchased directly from the Nucific website, you can get free shipping on US orders over $50. All orders ship within 24-48 hours of ordering and will take about 5 business days to arrive.

What is Nucific’s Return Policy?

If you’re not happy with your product, Nucific offers a 90-day money-back guarantee. You’ll get a full refund on the cost of the product.

How to Contact Nucific

If you have questions that I wasn’t able to answer in our Bio X4 review, you can contact Nucific using the following methods:

You can call the company from Monday to Friday between 7:00 AM to 5:00 PM PST, and on weekends from 7:00 AM to 4:00 PM PST.

For more digestive supplements, take a look at these brands:


Nature M.D.

Synbiotic 365


1MD Probiotics

Article Sources

[1] Avramidou, M., Angst, F., Angst, J., Aeschlimann, A., Rössler, W., & Schnyder, U. Epidemiology of gastrointestinal symptoms in young and middle-aged Swiss adults: prevalences and comorbidities in a longitudinal population cohort over 28 years BMC gastroenterology, 18(1), 1-10
[2] Almario, C. V., Ballal, M. L., Chey, W. D., Nordstrom, C., Khanna, D., & Spiegel, B. M. Burden of Gastrointestinal Symptoms in the United States: Results of a Nationally Representative Survey of Over 71,000 Americans The American journal of gastroenterology, 113(11), 1701
[3] Reid, G. Probiotics: definition, scope and mechanisms of action Best practice & research Clinical gastroenterology, 30(1), 17-25
[4] Sinn, D. H., Song, J. H., Kim, H. J., Lee, J. H., Son, H. J., Chang, D. K., ... & Rhee, P. L. Therapeutic Effect of Lactobacillus acidophilus-SDC 2012, 2013 in Patients with Irritable Bowel Syndrome Digestive diseases and sciences, 53(10), 2714-2718
[5] Arunachalam, K., Gill, H. S., & Chandra, R. K. Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019) European Journal of Clinical Nutrition, 54(3), 263-267
[6] Pavan, R., Jain, S., & Kumar, A. Properties and Therapeutic Application of Bromelain: A Review Biotechnology research international, 2012
[7] Chen, I. J., Liu, C. Y., Chiu, J. P., & Hsu, C. H. Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial Clinical Nutrition, 35(3), 592-599
[8] Hursel, R., Viechtbauer, W., & Westerterp-Plantenga, M. S. The effects of green tea on weight loss and weight maintenance: a meta-analysis International journal of obesity, 33(9), 956-961
[9] Kuriyan, R., Raj, T., Srinivas, S. K., Vaz, M., Rajendran, R., & Kurpad, A. V. Effect of Caralluma Fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women Appetite, 48(3), 338-344

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